Archive for category Health

Clinical Trials To Go Ahead On Anti-AIDS Vaginal Gel

UNAIDS and the World Health Organization have agreed to hold two further clinical trials on a vaginal gel, which shows promise in reducing the risk of HIV. Experts attending a meeting in Johannesburg, South Africa last week decided new trials should be conducted as quickly as possible to confirm preliminary hopeful results.

Results of the first study on the vaginal gel created a lot of excitement when they were presented at the International AIDS Conference in Vienna in July.

Chief Scientific Adviser to UNAIDS, Catherine Hankins says the gel was found to be 39 percent effective in protecting women from getting infected with HIV.

And, she says, the women who were using the gel more than 80 percent of the time they were having sex, had a 54 percent protection. “So, this was the first time ever that we have seen a positive result for a microbicide gel, which is a women initiated, women controlled product. So, the concern was how to rapidly move to make this product available to women. And, the results of the meeting were a consensus that two confirmatory trials were needed. And, these needed to get up and running very, very quickly,” she said.

Dr. Hankins explains every day that goes by, in which the gel is not available to women, about 2,500 more women get infected with HIV.

The World Health Organization reports about half the people living with HIV in the world are women. In sub-Saharan Africa, WHO says more women are infected than men. HIV is a major cause of maternal mortality.

Dr. Hankins says one of the new clinical trials will take place primarily in South Africa. Sexually active 16 and 17 year olds will use the gel 12 hours before sex and once during the 12-hour period after sex to test its safety and efficacy against HIV.

She says the second study will be conducted in other African countries. It will test if a single application of the gel before sex or immediately after sex, is as effective and safe as taking two doses.

During the original trial, she says women were told to use condoms along with the gel when they had sex, to lower the risk of infection. But, she notes there are times when using a condom is not desirable.

“When you are trying to get pregnant. When you are not seeing your guy very often, it is obvious you need some other mechanism. When we eventually market this, this will be marketed as something to be used with condoms and encourage male circumcision as well. All the methods need to be used in combination. That is why our basic message is combination prevention,” Hankins said.

Nearly 20 years of research have gone into microbicides. If confirmed, advocates say the tenofovir gel would empower women and allow them to protect themselves from HIV without requiring the cooperation of their male partner.

The first trials are likely to get under way early next year. The next phase of the research is estimated to cost $100 million.

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Obama Global Health Initiative Targets Maternal, Child Health, Disease

U.S. Secretary of State Hillary Clinton recently announced a new $63 billion Global Health Initiative with an emphasis on maternal and child health, family planning and programs to fight infectious diseases such as malaria, tuberculosis and HIV/AIDS.

“We need a comprehensive, effective global system for tracking health data, monitoring threats, and coordinating responses,” announced Clinton.

World health experts previously have worked together to combat various respiratory diseases, polio and other global outbreaks. The administration’s aim now is to tackle health problems that can be eliminated with relatively little investment, and to ensure health care for women and girls.

Terry Miller, an economist at the Heritage Foundation, agrees with some aspects of this approach.

“The focus of international and even public health services in many of our countries have always been primarily on infectious diseases and there has not been in way of resources moving internationally into non-infectious diseases like cancer or heart disease,” said Miller.

But Miller says the focus should go beyond improving the health of women and girls.

“I would like to have seen a little more emphasis on improving outcomes for a society as a whole in an equitable way across all genders,” added Miller.

Dr. Peter Hotez at the George Washington Medical Center wants the Global Health Initiative also to focus on medical research.

“A very important piece that I think is missing from the Global Health Initiative that I would like to see, and that is research and development for new drugs and new vaccines,” said Dr. Hotez. “GHI is extremely important providing life saving technologies that are already available, but who is going to be developing the next generation of those drugs and products?”

Secretary Clinton says the United States is standing by its commitment to fight HIV-AIDS. AIDS activists are concerned there is a waning interest in the disease.

“The AIDS epidemic is still an emergency. It hasn’t gone away and it will not go away,” said Sharone Ekambaram, a spokeswoman with Doctors Without Borders.

AIDS activists say if funding for HIV/AIDS is not increased, more children will be orphaned as their parents die from the disease and AIDs will once again devastate entire villages.

Dr. Hotez calls for a broader balance to public health. He says that along with HIV/AIDS, and maternal child health problems, there is a need for more funding in dealing with some of the other very important global health threats like neglected tropical diseases affecting billions of people worldwide.

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Frog Skin Oozes Possibly Powerful Antibiotic

Frogs secrete compounds that could be used to battle MRSA and a new emerging bacterium that affects many wounded soldiers in Iraq.

According to Mideast researchers, the amphibians could provide several new antibiotic compounds to fight drug resistant fungi and bacteria.

Worldwide threat

The emerging battle against drug-resistant bacteria poses a huge threat to public health worldwide. That threat has loomed larger as the number of effective antibiotic drugs has dwindled.

J. Michael Conlon, a biochemist at the United Arab Emirates University, says frog skin, which protects the amphibians from injury and disease, is coming to the rescue by providing a wealth of new antibiotic compounds to fight drug resistant fungi and bacteria.

“Frogs of necessity have to live in a warm moist environment that is very conducive to the growth of micro-organisms. They’ve been around for a long, long time, at least 300 million years” says Conlon. “So, it’s not so surprising that, over the course of evolution, they have developed defenses against these invading pathogens.”

Conlon has identified germ-fighting chemicals from more than 200 frog species from around the world by isolating peptides or strings of proteins that have the ability to kill bacteria and fungi.

He says the challenge is to get those agents to work in humans. “The problem is that as well as efficiently killing micro-organisms, they are to various degrees toxic to mammalian cells. So it’s not a great idea to cure infection if you kill the patient at the same time.”

Fighting two major pathogens

Conlon’s laboratory in the United Arab Emirates works with samples from frogs gathered collaboratively by scientists in Japan, France and the United States.

The naturally occurring compounds are first purified and then synthesized. At that point, structural changes are made in the molecules. The results have proved to be less toxic to human cells.

Conlon says the new compounds show promise in fighting two major pathogens, the well known methicillin-resistant Staphylococcus aureus (MRSA) and a new emerging bacterium, Acintobacter baumanni. “This has been called the Iraqibacter because many wounded soldiers in Iraq have developed infections by this microorganism.”

Frog mouthwash

Conlon also sees great potential for other antibiotic applications from creams and ointments for wounds to treatment of foot ulcers. He adds that the peptides have shown to be very effective against oral pathogens. “So we are interested in the possibility of incorporating of incorporating them into a mouth wash.”

But Conlon says as a researcher in a small university lab, he can only take the product so far. “To bring a drug from the laboratory to the pharmacy literally costs hundreds of millions of dollars. We really need a partner in the pharmaceutical industry with which to collaborate.”

Should that partner step forward, J. Michael Conlon predicts that some frog-skin derived compounds could make their way into clinical trials and into marketable drugs within five years.

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Rowling gives £10m for MS centre

Author JK Rowling is donating £10m to set up a multiple sclerosis research centre at Edinburgh University.

This article is from BBC News [visit resource]
Published on Tue, 31 Aug 2010 09:06:20 GMT

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MS activity ‘alters with seasons’

The severity of multiple sclerosis seems to change with the seasons, research suggests.

This article is from BBC News [visit resource]
Published on Tue, 31 Aug 2010 00:01:55 GMT

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Massive Egg Recall Raises Food Safety Questions

This month, authorities ordered more than half a billion eggs off the shelves at American supermarkets due to fears of salmonella. More than 1,000 people have become sick after eating eggs contaminated with the disease-causing bacteria.

It’s the largest salmonella outbreak ever recorded in the U.S., and the most recent in a series of high-profile food borne disease outbreaks in recent years.

The outbreak may give new momentum to an effort to update U.S. food safety laws.

Deadly contamination

Ohio resident Randy Napier lost his mother in another recent food safety failure.

Shortly after New Year’s Day last year, his 80-year-old mother, Nellie, became sick with several days of severe diarrhea.

“The only thing she likes to snack on is peanut butter on bread. So that’s all she was eating,” he says.

But as the Napiers soon discovered, peanut butter was at the center of a nationwide outbreak of salmonella. By the time doctors identified it as the culprit, Nellie was hospitalized. Her organs soon shut down.

Randy says she was in tremendous pain. “It was about four, five days of – excuse the language – just utter hell.”

She died on January 26. Eight others died during the outbreak and more than 700 people in 46 states got sick.

Massive recall

The U.S. Food and Drug Administration recalled nearly 4,000 products and countless individual items, including crackers, cookies, cereal, ice cream and even dog food.

The scope of the outbreak surprised Randy Napier. “I could not even imagine something you go into the store and you buy off the shelf would kill you.”

All those products on store shelves across the country had one thing in common: they all contained peanuts produced by a single company: the Peanut Corporation of America.

This month, a new salmonella outbreak has triggered an FDA recall of more than 500 million eggs produced by two closely-linked farms.

The reason for these huge outbreaks has a lot to do with how Americans get their food today. Food manufacturers have gotten bigger and more efficient, pushing out most small, local operations.

“Foods are produced in large quantities and distributed widely across the country,” says epidemiologist Robert Wallace at the University of Iowa. “And when there’s a problem in the safety of that food, a lot of people are then exposed, and it’s over a broad geographic area. And that’s really the problem.”

Illness not on the rise

But despite the big numbers when problems occur, Wallace says it’s hard to know whether America’s overall food safety is really suffering because most cases of food poisoning go unreported.

According to the best data available from the Centers for Disease Control and Prevention, rates of salmonella infection haven’t changed much in the last decade, and rates of many other food borne illnesses are declining.

While it’s impossible to reduce outbreaks to zero, America’s food supply is one of the safest in the world, according to Kelli Ludlum with the American Farm Bureau Federation, the nation’s largest farmers’ group. It’s also “what allows us to enjoy foods that we probably wouldn’t be able to otherwise,” she says.

Ludlum adds that Americans have made trade-offs for their modern food supply.

“Personally, I wouldn’t want to go back to the food supply of 50 years ago. I don’t cook that much. I certainly don’t [preserve], so having to provide for myself all those things would be more than just inconvenient.”

Outdated law

But while the way Americans feed themselves has changed over the last 50 years, the law governing food safety haven’t, according to Erik Olson, head of food safety at the research and advocacy group the Pew Charitable Trusts.

“Right now in the United States, we have an antiquated law that’s over 70 years old,” he says, “and it reacts to contamination problems rather than preventing them.”

Congress is considering updating that law, and the latest outbreak may give that effort a push.

“Certainly FDA does need more resources. We’ve said that for a long time,” says the Farm Bureau’s Kelli Ludlum. “And they need more direction on how to use those resources.”

The House of Representatives passed a food safety bill last year, but the Senate has not passed its version. Randy Napier, who lost his mother to Salmonella, is heading to Washington, DC, soon with a message for his senators.

“Granted, things are going to cost a little more to be safer,” he says. “But it has to be safer. It has to be. Or the people are just gonna keep dying.”

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Heart drug ‘an exiting discovery’

Professor Martin Cowie explains how a new drug “slows the pulse down and so helps to take the strain off the heart”

This article is from BBC News [visit resource]
Published on Mon, 30 Aug 2010 09:04:19 GMT

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Pill may ‘cut heart failure rate’

A pill costing less than £1.50 a day has the potential to save the lives of thousands of heart failure patients, research suggests.

This article is from BBC News [visit resource]
Published on Mon, 30 Aug 2010 04:31:14 GMT

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Motion capture clue to human behaviour

The system of digitising actors to create characters in films like Avatar is being used to measure human behaviour in real life.

This article is from BBC News [visit resource]
Published on Mon, 30 Aug 2010 05:23:27 GMT

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Male oesophageal cancer ‘doubles’

Cancers of the food pipe in Britain have doubled in men over 25 years, figures from Cancer Research UK show.

This article is from BBC News [visit resource]
Published on Sat, 28 Aug 2010 10:08:25 GMT

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